What is better Phazostabil or Cardiomagnyl?

The mechanism of action of acetylsalicylic acid (ASK) is irreversible inhibition of cyclooxygenase (COX-1), as a result of which synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. It is believed that ASA has other mechanisms for the suppression of platelet aggregation, which expands its field of application in various vascular diseases. ASA also has anti-inflammatory, analgesic, antipyretic effect. The anti-inflammatory effect is associated with a decrease in blood flow due to inhibition of prostaglandin E2 synthesis. Magnesium hydroxide, which is part of the drug Phasostabil, has an antacid effect and protects the mucous membrane of the gastrointestinal tract from the effects of ASA.

Indications for use

- Primary prevention of cardiovascular diseases such as thrombosis and acute heart failure with risk factors (for example, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age). - Prevention of recurrent myocardial infarction and thrombosis of blood vessels. - Prevention of thromboembolism after surgical interventions on the vessels (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty). - Unstable angina

Contraindications

- Hypersensitivity to ASA, auxiliary substances and other nonsteroidal anti-inflammatory drugs (NSAIDs), - Brain hemorrhage, - Bleeding tendency (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis), - Chronic heart failure of functional class III-IV by classification NYHA, - Bronchial asthma, induced by salicylates and NSAIDs, - Complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance and ASA or other NSAIDs, including inhibitors of cyclooxygenase-2 (COX-2) (including in history), - Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase), - Gastrointestinal bleeding, - Severe renal failure ( creatinine clearance (KK) less than 30 ml / min.), - Hepatic insufficiency (class B and C according to Child-Pugh classification), - Pregnancy (I and III trimesters), breastfeeding period, - Deficiency of glucose-6-phosphate dehydrogenase, - Simultaneous administration with methotrexate (more than 15 mg per week), - Children under 18 years of age.

Dosage and administration

Inside, the film-coated tablets of the drug Phasostabil are swallowed whole with water. The drug Phasostabil intended for long-term treatment. The duration of treatment is determined by the doctor. - Primary prevention of cardiovascular diseases such as thrombosis and acute heart failure with risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age) 1 tablet of the Phasostabil preparation containing ASA in the first 150 mg dose day, then 1 tablet containing ASA in a dose of 75 mg 1 time per day. - Prevention of recurrent myocardial infarction and thrombosis of blood vessels 1 tablet of the drug Phasostabil, containing ASA in a dose of 75-150 mg 1 time per day. - Prevention of thromboembolism after surgical interventions on the vessels (coronary artery bypass surgery, percutaneous transluminal coronary angioplasty) 1 tablet of the Phasostabil preparation containing ASA in a dose of 75-150 mg 1 time per day. - Unstable angina 1 tablet of the drug Fazostabil, containing ASA in a dose of 75-150 mg 1 time per day. When you skip the next dose of the drug Fazostabil, you must take the missed dose of the drug as soon as the patient remembers it. In order to avoid doubling the dose, you should not take the missed pill if the time of taking the next dose is approaching. Peculiarities of the action at the first intake or withdrawal of the drug were not observed.

Release form

Tablets, film coated 75 mg + 15.2 mg and 150 mg + 30.39 mg. On 10, 20, 25 or 30 tablets in a blister strip packaging from a film of polyvinyl chloride and aluminum foil printed lacquered. One can or 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 blister packs together with the instructions for use are placed in a carton (pack).

Description and Comparison

Phasostabil - a well-known antiplatelet agent, produced in Russia by the company "Ozone". Tablets are available in enteric film-coated membrane, which reduces the risk of damage to the gastrointestinal tract. Tablets are oval, white with marbling, biconvex, equipped with a risk for division. The price for 50 tablets is 218 rubles.

The dosage of the drug is 150 + 30.39 mg, as well as 75 + 15.2 mg.

As part of the drug - acetylsalicylic acid (ASA) in a volume of 150 or 75 mg, it is considered the main active ingredient. To supplement the therapeutic action, magnesium hydroxide is added to the composition - 30.39 mg or 15.2 mg.

When buying drugs to thin the blood, patients wonder what is better - Fazostabil or Cardiomagnyl? According to the testimony and composition of Cardiomagnyl does not differ from Phasostabil. It contains the same amounts of magnesium hydroxide and acetylsalicylic acid, produced in similar dosages. The price of the drug - from 170 to 300 rubles per 100 tablets, therefore, there are no differences in the cost either. The drug is manufactured by Takeda.

Additional substances tablets of both types:

  • cellulose,
  • magnesium stearate,
  • macrogol,
  • hypromellose.

There is a slight difference in the composition of other auxiliary components. So, in Cardio Magnetic there is povidone, titanium dioxide, croscarmellose sodium. In Phasostabil present corn starch and potato starch, talc. One or another remedy may be better only for those who are allergic to these substances, otherwise the remedies are completely interchangeable.

Drug action

The structure includes ASA, which belongs to nonsteroidal anti-inflammatory drugs. This substance works according to the following mechanism: it inhibits the release of the COX-1 enzyme, which leads to a blockage of the production of thromboxane A2. In the end, this leads to a decrease in the process of gluing platelets. ASC acts on other mechanisms that are not well understood, but lead to a similar result. Among other things, the substance has the following actions:

In addition to ASC, magnesium is present in the composition in the form of hydroxide. It is intended to protect the gastric mucosa from the destructive action of acetylsalicylic acid. Magnesium hydroxide is an antacid, it envelops the mucous membrane and prevents the inflammatory process. The drug has full absorbability and high availability, but if you drink it with a meal, the effectiveness decreases. In women, the processing and elimination of ASA occurs more slowly, as in liver and kidney diseases.

Indications of Phasostabil and Cardiomagnyl

Medicines should be taken with a large range of cardiovascular diseases. Most often, the appointment of Cardiomagnyl and its analogue is associated with the prevention of the development of thrombosis and thromboembolism when the patient has risk factors:

  • elderly age,
  • long-term tobacco smoking,
  • diabetes,
  • obesity,

To prevent the formation of blood clots, as well as to prevent heart failure, agents are prescribed in the complex treatment of atherosclerosis and hypertension. In case of a postponed heart attack, Cardiomagnyl is most often recommended for lifelong intake to prevent recurrent episodes. The drugs are also indicated for ischemic disease with normal or unstable angina.

After an operation on the heart vessels (angioplasty, bypass surgery), the drugs will not allow thromboembolism.

Contraindications include intolerance, allergy to acetylsalicylic acid, other components. It is strictly forbidden to be treated with an agent for cerebral hemorrhage, severe vitamin K deficiency, thrombocytopenia, and hemorrhagic diathesis. Admission may result in uncontrolled bleeding. Other prohibitions:

  • 1.3 trimesters of gestation,
  • age up to 18 years
  • erosion, gastric ulcer in the acute stage,
  • severe renal failure

Under the supervision of a physician, they use medications for gastritis and an ulcer in history, for gout, bronchial asthma, nasal polyposis, in 2 trimester in pregnant women.

Instructions for use

Medications are taken the same way, there is no difference between the order of therapy. Both of them are intended for long-term courses, but the exact duration of treatment is determined by the doctor according to the patient's condition. Drink pills with water. Often, Panangin, Asparkam and other cardiac medications are prescribed with them.

If necessary, the pill can be divided by risk.

Reception is carried out in the morning, an hour after meals. It is usually recommended to drink Phasostabil or Cardiomagnyl once a day. Here are the dosing tips:

    prevention of thrombosis, acute heart failure - 150 g on the first day, then 75 mg long (dose for people with risk factors),

If the patient misses an appointment, you can take a pill at any time, even in the evening. If the time of the next dose is near, they are taking the dose, doubling the dose is not allowed. Overdose is strictly prohibited, especially in elderly patients. Acute poisoning develops with consumption of more than 100 mg / kg of body weight. Treatment only in the hospital!

What is better than Acardacal or Cardiomagnyl?

Atzacardol and Cardiomagnyl are analogues with a similar effect on the body. The difference between drugs is insignificant, and the instructions for use are almost the same. Features of each medication and the main differences between them:

  1. Producing country. Atsekardol - the Russian drug, and Cardiomagnyl is produced in Germany.
  2. Drug price. Analogue, produced in Russia, is several times cheaper than foreign.
  3. Pill form. German medicine is produced in the form of hearts, as well as in the form of ellipsoids with a notch in the middle. Russian manufacturer manufactures standard round pills.
  4. Dosage of active ingredient (aspirin). One heart pill contains 75 mg of the active ingredient, an oval pill contains 150 mg. The Russian equivalent contains 50, 100 and 300 mg of aspirin.
  5. The composition of the drug. Most consumers believe that Cardiomagnyl is better than Acardardol because it contains magnesium hydroxide, which protects the gastrointestinal tract from negative effects.

Tsekardol - one of the drugs-analogues, also having anti-inflammatory and blood thinning effect. However, it is better to consult a cardiologist to choose the right remedy.

Analogs and side effects

A cheaper equivalent is the drug Trombital (the price for 100 tablets is 230 rubles). Other means can be selected from the list, all have an antiplatelet effect. Many do not contain a protective component that must be considered in the treatment of:

MedicineCompositionPrice, rubles
TrombomegASC, magnesium hydroxide320
Trombo - ACC (Tromboass)ASC150
ASC-CardioASC110
CardiaskASC70
Aspirin CardioASC140
AtsekardolASC25
CoplavixASK, Clopidogrel3000
AgrenoxASA, Dipyridamole1000

From side effects sometimes allergic reactions occur, sometimes they reach a severe degree, even anaphylaxis. Most often develop urticaria, rash, redness of the skin. On the part of the gastrointestinal tract can be nausea, heartburn, pain in the abdomen and stomach. In severe cases, stomach ulcers and gastritis exacerbations occur. Occasionally recorded bleeding from the digestive tract, erosion of the esophagus, esophagitis. With a long reception, a number of patients had strictures of the esophagus. Often develop irritable bowel syndrome.

International non-proprietary name

The INN for this medicine is Acetylsalicylic acid + Magnesium hydroxide.

In the international classification of ATC, the drug has the code B01AC30.

The drug is available in the form of tablets coated with a protective film coating.

Forms of release and composition

The drug is available in the form of tablets coated with a protective film coating. Dosage tablets - 75 mg and 150 mg. The main active ingredients of the drug are acetylsalicylic acid in a dose of 75 or 150 mg and magnesium hydroxide in the amount of 15 or 30 mg. In addition, the preparation includes such auxiliary components as starch, talc, hypromellose, magnesium stearate, macrogol and cellulose.

Tablets with a dosage of 75 mg are in the form of a stylized heart. The drug with a dosage of 150 mg is oval. Tablets are packaged in plastic cellular packs of 10 pcs. Blisters are packed in cardboard packs, in which the instruction is put.

Pharmacokinetics

Phasostabil active components are almost completely absorbed in the walls of the gastrointestinal tract. With the participation of liver enzymes, the active substance is converted into salicylic acid. The maximum concentration in the blood plasma of the active components and their metabolites is reached after about 1.5 hours. The active components of the drug are almost completely bound to plasma proteins. The breakdown products of the drug are eliminated from the body in about 2 days.

Phasostabil active components are almost completely absorbed in the walls of the gastrointestinal tract.

What helps?

The use of Phasostabil is shown in the framework of the prevention of diseases of the heart and blood vessels, including heart failure. Often this medication is administered in maintenance doses to people at risk of developing heart disease, including patients suffering from diabetes, obesity, arterial hypertension. The agent can be prescribed for blood thinning as part of the prevention of recurrent myocardial infarction or acute thrombosis.

In addition, this medication can be used for pulmonary embolism. This medication is often prescribed for the treatment of unstable angina. In addition, the drug can be used in the prevention of thrombosis after surgery on vessels.

Carefully

Particular caution requires the use of Phasostabil in the treatment of patients suffering from hyperuricee or gout. In addition, special control by doctors is required when using this drug in the treatment of patients who have a history of gastrointestinal bleeding.

The use of Phasostabil is shown in the framework of the prevention of diseases of the heart and blood vessels, including heart failure.
Often this medication is prescribed to people with diabetes.
Often this medication is prescribed to people who are obese.
The drug can be used in the prevention of thrombosis after operations on the vessels.

Gastrointestinal tract

On the part of the gastrointestinal system, side effects are observed most frequently. Patients often have heartburn, nausea and vomiting. Possible abdominal pain. Increased risk of developing stomatitis, colitis, erosive damage to the mucous membrane of the upper GI tract, etc.

Nausea - one of the side reactions of the body to receive the drug.

On the part of the skin

In the presence of individual intolerance, skin rash and itching may occur.

In the presence of individual intolerance, skin rash and itching may occur.

Often, patients with Phasostabil have a urticaria. Anaphylactic shock and angioedema may develop.

Use in violation of the liver

For patients with reduced liver function, the drug is prescribed only under strict indications.


Children are not given this medication.
The use of Phasostabil during pregnancy is not recommended.
The use of phasostabil in the treatment of patients with reduced kidney function requires special monitoring.
For patients with reduced liver function, the drug is prescribed only under strict indications.


Compatibility with alcohol

When therapy with Phasostabil should refuse to take alcohol.

When therapy with Phasostabil should refuse to take alcohol.

For drugs that have a similar effect include:

  1. Cardiomagnyl.
  2. Trombot ass.
  3. Trombital.
  4. Clopidogrel.
  5. Plugged

Doctors reviews about Phasostabil

Vladislav, 42, Moscow

Middle-aged patients who are at risk of developing heart disease are often prescribed Phazostabil. In most cases, I recommend a minimum dose of 20 mg first and then slowly increase it. This reduces the risk of adverse effects. Take the tool you need long courses.

Irina, 38 years old, Chelyabinsk

In my practice I often prescribe Phasostabil to patients with a high risk of blood clots. The tool reduces the risk of thromboembolism and other complications of thrombosis. Medication rarely causes side effects in patients. In this case, a replacement of the drug by analogue is required.

Patient Reviews

Igor, 45, Rostov-on-Don

About 3 years ago I first got to the hospital with angina. After stabilization of the condition, the doctor prescribed taking Phasostabil. I accept the remedy every day. The condition does not worsen. In addition, the low price of the drug is good.

Kristina, 58 years old, Vladivostok

For many years I suffer from arterial hypertension. I take drugs to stabilize the pressure. About a year ago, the doctor prescribed Phazostabil, but the drug is not suitable for me. After the first pill, severe nausea, vomiting and abdominal pain appeared. From the use of this tool had to be abandoned.

Indications for use: what is prescribed

Phasostable is indicated for use in such cases:

  • as a preventive measure, to prevent obstruction of the veins after surgery on the vascular system (percutaneous transluminal coronary angioplasty, coronary artery bypass surgery),
  • to prevent the occurrence of blood clots in the circulatory system and the re-formation of myocardial infarction,
  • for therapeutic purposes against the background of unstable angina,
  • in the form of primary preventive measures to prevent the development of acute insufficiency in the heart and blood clots in the vessels on the background of triggers such as diabetes, hypertension, smoking, elevated blood lipids, obesity, old age.

Special instructions

Acetylsalicylic acid, which is the active component of Phazostabil, can cause the formation of an attack of bronchial asthma, bronchospasm and other hypersensitivity reactions.

The risk group includes people who have bronchial asthma in their anamnesis, allergies to other medications, chronic respiratory diseases, polyposis in the nose and accessory cavities, pollinosis (hay fever).

In the event that surgery is pending, it is necessary to inform the doctor that the patient is taking medications containing acetylsalicylic.

If there is a predisposition to the formation of diseases of the heart and vascular system, it is necessary to avoid the simultaneous use of aspirin with ibuprofen. In the case of ibuprofen to relieve pain, you must notify the doctor.

The first weeks of treatment with Phasostabil and Methotrexate (maximum 15 mg during the week) must be donated blood for laboratory testing every week. Carefully monitor the situation is necessary, if there are violations in the renal functions (even minimal), people of the older age category.

If lithium-containing agents or digoxin are prescribed in parallel with Phasostabil, control of the content of these substances in the blood plasma is required. This test is recommended to be carried out at the initial stage of treatment or at the end. In some cases, dosage may be changed.

Important! If Phasostabil treatment is prescribed for a long time, it is necessary to carry out laboratory diagnostics of fecal masses for the presence of hidden blood, a clinical blood test, to check how the hepatic system functions.

Acetylsalicylic acid in the maximum dosage is capable of hypoglycemic effects, which must be taken into account if a person is diagnosed with diabetes.

Preparations containing acetylsalicylic acid in the minimum dosage contribute to a decrease in the excretion of urea, and also sometimes lead to the formation of gout in people with reduced urea, who have a tendency to this condition.

With a serious lack of glucose-6-phosphate dehydrogenase, aspirin can cause the formation of hemolytic anemia and hemolysis. The risk group in this case includes patients taking high-dosage aspirin-based drugs, as well as people with acute infection and fever.

During pregnancy and lactation period

It is forbidden to take the drug during lactation.

Taking Phasostable is contraindicated for women in the position during the 1st and 3rd trimester. During the 2nd trimester, medication may be prescribed in a daily dosage of a maximum of 150 mg in the form of a short-term course of treatment.

Before you begin to use, it is necessary to assess the ratio of the possible danger to the future baby with the benefit for the mother.

It is impossible to use Phasostabil in the process of breastfeeding.

Phasostabil or Trombos Ass: which is better

These medicines are full analogs of the active component. However, a thrombotic drug of domestic production (Phasostabil) is as effective as a foreign antiagregant. In addition, Phasostabil is much cheaper, which is another advantage of this tool.

Phazostabil and Cardiomagnyl: what are the differences

Cardiomagnyl is produced in two types, the difference between which is in dosage. One of the variations is a direct analogue of Phasostable (it contains acetylsalicylic acid and magnesium hydroxide in a smaller amount). As a result, if Cardiomagnyl is prescribed with a content of active ingredients in the amount of 150 and 30.39 mg (per 1 tablet), there is a possibility that the effect will be stronger. A positive result in this case can be obtained sooner. Although there is a more intensive development of negative pathological reactions. As a consequence, there is a possibility of increasing the risk of complications, especially in relation to the gastrointestinal tract.

List of analogues

With regard to drugs with a similar effect, among them can be noted:

TitlePrice
ThromboMagfrom 45.00 rub. up to 359.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 30
Evropharm RUtrombomeg 150 plus 30,39 mg 30 tabl 45.00 rub.Nizhpharm AO / Hemofarm LLC
Evropharm RUthrombium 75 plus 15.2 mg 30 tabl 124.00 rub.Hemofarm
amount in the package - 100
Evropharm RUthrombium 75 plus 15.2 mg 100 tabl 219.00 rub.Hemofarm
Evropharm RUthrombogen 150 plus 30.39 mg 100 tabl 359.00 rub.Nizhpharm AO / Hemofarm LLC
Trombo Assfrom 46.80 rub. up to 161.60 rubleshide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 28
Evropharm RUthrombotic ass 50 mg 28 tabl 46.80 rub.Lannaher Heilmittel GmbH / G.L.
Pharmacy DialogueThrombot ACC (tab.p.pl / ob.50mg №28) 48.00 rub.Austria
Evropharm RUthrombotic ass 100 mg 28 tabl 53.90 rub.G.L.Farma GmbH
Pharmacy DialogueTrombot ACC (tab.p.pl / ob.100mg №28) 57.00 rub.Austria
amount in the package - 100
Pharmacy DialogueThrombot ACC (tab.p.pl / ob.50mg №100) 123.00 rub.Austria
Pharmacy DialogueThrombone ACC tablets 100mg №100 132.00 rub.Austria
Evropharm RUthrombotic ass 50 mg 100 tabl 138.90 rub.Lannaher Heilmittel GmbH / G.L.
Evropharm RUthrombotic ass 100 mg 100 tabl 161.60 rub.Lannaher Heilmittel GmbH / G.L.
Trombitalfrom 76.00 rub. up to 228.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 30
Evropharm RUtrombital 75 mg 30 tabl 76.00 rub.JSC Pharmstandard-Lexredst RU
Evropharm RUtrombital forte 150 mg table 30 120.00 rub.Pharmstandard-Leksredstva
amount in the package - 100
Pharmacy DialogueTrombital tablets 75mg + 15.2mg №100 158.00 rub.RUSSIA
Evropharm RUthrombital 75 mg 100 tabl 165.00 rub.Pharmstandard-Leksredstva
Evropharm RUtrombital forte 150 mg 100 tabl 210.00 rub.JSC Pharmstandard-Lexredst RU
Pharmacy DialogueTrombital forte tablets 150mg + 30,39mg №100 228.00 rub.RUSSIA
Trombitalfrom 76.00 rub. up to 228.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 30
Evropharm RUtrombital 75 mg 30 tabl 76.00 rub.JSC Pharmstandard-Lexredst RU
Evropharm RUtrombital forte 150 mg table 30 120.00 rub.Pharmstandard-Leksredstva
amount in the package - 100
Pharmacy DialogueTrombital tablets 75mg + 15.2mg №100 158.00 rub.RUSSIA
Evropharm RUthrombital 75 mg 100 tabl 165.00 rub.Pharmstandard-Leksredstva
Evropharm RUtrombital forte 150 mg 100 tabl 210.00 rub.JSC Pharmstandard-Lexredst RU
Pharmacy DialogueTrombital forte tablets 150mg + 30,39mg №100 228.00 rub.RUSSIA
Cardiomagnylfrom 115.00 rub. up to 399.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 30
Pharmacy DialogueCardiomagnyl tablets 75mg + 15.2mg №30 115.00 rub.Austria
Pharmacy DialogueCardiomagnyl (tab.p.pl / v.75mg + 15.2mg №30) 121.00 rub.Japan
Evropharm RUcardiomagnyl 75 mg table 30 135.00 rub.Takeda GmbH
Pharmacy DialogueCardiomagnyl (tab.p.pl / ob.150mg + 30,39mg №30) 187.00 rub.Japan
amount in the package - 100
Pharmacy DialogueCardiomagnyl tablets 75mg + 15.2mg №100 200.00 rub.Austria
Pharmacy DialogueCardiomagnyl (tab.p.pl / v.75mg + 15.2mg №100) 202.00 rub.Japan
Evropharm RUcardiomagnyl 75 mg 100 tabl 260.00 rub.Takeda Pharmaceuticals Ltd.
Pharmacy DialogueCardiomagnyl tablets 150mg + 30,39mg №100 341.00 rub.Japan
Cardiomagnylfrom 115.00 rub. up to 399.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 30
Pharmacy DialogueCardiomagnyl tablets 75mg + 15.2mg №30 115.00 rub.Austria
Pharmacy DialogueCardiomagnyl (tab.p.pl / v.75mg + 15.2mg №30) 121.00 rub.Japan
Evropharm RUcardiomagnyl 75 mg table 30 135.00 rub.Takeda GmbH
Pharmacy DialogueCardiomagnyl (tab.p.pl / ob.150mg + 30,39mg №30) 187.00 rub.Japan
amount in the package - 100
Pharmacy DialogueCardiomagnyl tablets 75mg + 15.2mg №100 200.00 rub.Austria
Pharmacy DialogueCardiomagnyl (tab.p.pl / v.75mg + 15.2mg №100) 202.00 rub.Japan
Evropharm RUcardiomagnyl 75 mg 100 tabl 260.00 rub.Takeda Pharmaceuticals Ltd.
Pharmacy DialogueCardiomagnyl tablets 150mg + 30,39mg №100 341.00 rub.Japan
Exedrinefrom 179.00 rub. up to 340.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 10
Pharmacy DialogueExcedrin (tab.p.pl./ab.№10) 179.00 rub.USA
Evropharm RUexedrin 10 tabl 210.00 rub.NOVARTIS CONSUMER HELS SA
amount in the package - 20
Pharmacy DialogueExedrine (tab.p.pl./ab. No. 20) 299.00 rub.USA
Evropharm RUexedrin 20 tabl 340.00 rub.NOVARTIS CONSUMER HELS SA
Agrenoxfrom 1060.00 rub. up to 1060.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Evropharm RUagrenox 30 caps 1060.00 rub.Beringer Ingelheim International GmbH
Coplavixfrom 1106.00 rub. up to 8350.00 rub.hide watch prices in detail
PharmacyNamePriceManufacturer
Packing Quantity - 28
Pharmacy DialogueCoplavix (tab. P / o 100mg + 75mg №28) 1106.00 rub.France
Evropharm RUCoplavix 100 mg plus 75 mg 28 tabl 1390.00 rub.SANOFI-VINTROP INDUSTRY
amount in the package - 100
Pharmacy DialogueCoplavix (tab. P / o 100mg + 75mg №100) 3959.00 rub.France
Evropharm RUCoplavix 100 mg plus 75 mg 100 tabl 8350.00 rub.Sanofi-Winthrop Industrie

Price and terms of vacation in pharmacies

Phasostable can be purchased at pharmacies without a prescription from a doctor. A pack of 10 tablets costs between 130-218 rubles.

Reviews of the drug for the most part positive. Phasostabil often prescribed for problems with the heart and blood vessels, it is considered a harmless and effective medicine. The occurrence of negative pathological reactions in the process of treatment with this drug is observed in rare cases.

Pharmacodynamics

The action of Phasostabil is due to the properties of its active ingredient, acetylsalicylic acid (ASA). It irreversibly inhibits cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A is blocked2 and inhibition of platelet aggregation. It is believed that ASA has other mechanisms for the suppression of platelet aggregation, which expands its field of application in patients with various vascular diseases. The drug also has antipyretic, anti-inflammatory and analgesic effect.

Magnesium hydroxide - the second active component of Phasostabil - has an antacid effect, protects the mucous membrane of the gastrointestinal tract (GIT) from the irritant effect of ASA.

With abnormal liver function

Phasostable is contraindicated in case of hepatic insufficiency of class B and C according to Child-Pugh classification (moderate and severe degree).

The drug should be used with caution when treating patients with hepatic insufficiency of class A according to the Child-Pugh classification (mild severity), it is necessary to regularly monitor liver function.

Drug interactions

ASA enhances the effect and increases the toxicity of the following drugs:

  • valproic acid - due to its ousting from association with plasma proteins,
  • methotrexate - due to a decrease in renal clearance and its displacement from association with plasma proteins.

ASA increases the impact and risk of side effects of the following drugs:

  • sulfonamides, including co-trimoxazole, by increasing their concentration in the blood plasma and expelling them from their association with plasma proteins,
  • other NSAIDs, narcotic analgesics - due to synergism of action,
  • carbonic anhydrase inhibitors, including acetazolamide - salicylates can increase their toxicity against the central nervous system and the likelihood of severe acidosis,
  • lithium and digoxin - due to a decrease in their renal excretion and a decrease in plasma concentrations,
  • selective serotonin reuptake inhibitors, including sertraline and paroxetine - as a result of synergism with ASA increases the risk of bleeding from the upper GI tract,
  • antiplatelet agents, including clopidogrel and dipyridamole, indirect anticoagulants, including ticlopidine and warfarin, thrombolytic agents, heparin - due to the exclusion of the main therapeutic effects from plasma proteins and synergism,
  • hypoglycemic oral agents that are derivatives of sulfonylurea, and insulin - because ASA in daily doses of more than 2000 mg exhibits hypoglycemic activity, in addition, it displaces sulfonylurea derivatives from the association with plasma proteins,
  • ethanol and alcoholic beverages - due to the additive effect, the damage of the gastrointestinal tract mucous membrane is enhanced and the bleeding time is prolonged.

The following drugs reduce the antiplatelet property of ASC:

  • Kolestiramine and antacids containing magnesium and / or aluminum hydroxide - due to a decrease in the absorption of ASA in the gastrointestinal tract,
  • systemic glucocorticosteroids, with the exception of hydrocortisone, prescribed as replacement therapy for Addison's disease - due to increased elimination of salicylates,
  • ibuprofen - due to the manifestation of antagonist properties in relation to the suppression of platelet aggregation.

In low doses, ASA weakens the effect of uricosuric drugs (sulfinpyrazone, probenecid, benzbromarone), which is caused by competitive tubular elimination of uric acid.

In high doses, ASA is able to reduce the hypotensive effect of diuretics (due to a decrease in the glomerular filtration rate against the suppression of renal prostaglandin synthesis) and antihypertensive drugs. In particular, ASA can reduce the effect of ACE inhibitors due to the competitive blockade of prostacyclin synthesis.

The analogs are Fazostabila Agrenoks, Antagreks, Aspirin Cardio Brilinta, Ventavis, Detromb, Ilomedin, Zilt, Cardiomagnyl, Klapitaks, Kardogrel, Clopidogrel, Lirta, Monafram, Plavix, Sanovask, Trombeks, Trombomag, Flyuder, Effient, Egitromb et al.

The price of phazostabil in pharmacies

The price of Phasostabil depends on the dosage, the number of tablets in the package, as well as the region of sales and the pharmacy chain that sells the drug.The approximate cost for a package of 100 film-coated tablets, 75 mg + 15.2 mg is 133–154 rubles, 150 mg + 30.39 mg - 198–325 rubles.

How to apply: dosage and treatment

Primary prevention of cardiovascular diseases such as thrombosis and acute heart failure with risk factors:

1 tablet of Phazostabil preparation containing ASA in a dose of 150 mg on the first day, then 1 tablet each, containing ASA in a dose of 75 mg 1 time per day.

Prevention of recurrent myocardial infarction and thrombosis of blood vessels

1 tablet of the drug Phasostable containing ASA in a dose of 75-150 mg 1 time per day.

Prevention of thromboembolism after surgical interventions on the vessels (coronary artery bypass surgery, percutaneous transluminal coronary angioplasty)

1 tablet of the drug Phasostable containing ASA in a dose of 75-150 mg 1 time per day.

1 tablet of the drug Phasostable containing ASA in a dose of 75-150 mg 1 time per day.

Side effects

On the part of the immune system: infrequently - urticaria, angioedema (angioedema), skin rash, pruritus, rhinitis, swelling of the nasal mucosa, very rarely - anaphylactic shock, cardio-respiratory distress syndrome.

On the part of the kidneys and urinary tract: very rarely - impaired renal function.

On the part of the nervous system: often - headache, insomnia, infrequently - dizziness, drowsiness, rarely - tinnitus, intracerebral hemorrhage.

Hemolysis and hemolytic anemia have been reported in patients with severe deficiency of glucose-6-phosphate dehydrogenase.

From the side of blood and lymphatic system: very often - increased bleeding, rarely - anemia, very rarely - aplastic anemia, hypoprothrombinemia, thrombocytopenia, neutropenia, leukopenia, eosinophilia, agranulocytosis.

The respiratory system, chest organs and mediastinum: often - bronchospasm.

From the gastrointestinal tract: very often - heartburn, often - nausea, vomiting, infrequently - pain in the abdomen, ulcers of the mucous membrane of the stomach and duodenum, including perforative (rare), gastrointestinal bleeding, very rarely stomatitis, esophagitis, erosive lesions of the upper gastrointestinal tract (including strictures), colitis, irritable bowel syndrome.

Interaction

With the simultaneous use of ASA enhances the effect and increases the risk of toxicity:

- methotrexate (by reducing renal clearance and displacing it from the association with plasma proteins),

- valproic acid (due to the displacement of plasma blood from its association with proteins),

ASA enhances the effect and increases the risk of adverse reactions:

- narcotic analgesics, other nonsteroidal anti-inflammatory drugs (due to synergism of action)

- hypoglycemic agents for oral administration (sulfonylurea derivatives) and insulin due to the hypoglycemic properties of the ASA itself in high doses (more than 2 g per day) and forcing out sulfonylurea derivatives from the association with plasma proteins

- thrombolytic agents, heparin, indirect anticoagulant (ticlopidine, warfarin), antiplatelet agents (including clopidogrel, dipyridamole) - due to the synergism of the main therapeutic effects and the displacement of blood plasma from its association with proteins.