How to use the drug Amoxicillin 1000?

Bacterial infections caused by susceptible pathogens: respiratory tract infections (bronchitis, pneumonia) and ENT organs (sinusitis, pharyngitis, tonsillitis, acute otitis media), genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis), abdomine infections (peritonitis, cholangitis, cholecystitis), infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatosis), leptospirosis, listeriosis, Lyme disease (borreliosis), gastrointestinal tract (dysentery, salmonellosis, salmonella carriage) meningitis, endocarditis (pr preventive maintenance), sepsis.

Dosage Form

granules for suspension for oral administration, capsules, powder for preparing drops for oral administration for children, powder for preparing a solution for intravenous and intramuscular administration, powder for preparing a suspension for

Contraindications

Hypersensitivity (including to other penicillins, cephalosporins, carbapenems) .C caution. Polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics), renal failure, pregnancy, lactation.

How to apply: dosage and treatment

Inside, before or after a meal, the tablet can be swallowed whole, divided into parts or chewed with a glass of water, or diluted in water to form a syrup (in 20 ml) or a suspension (in 100 ml). Adults and children over 10 years old (with a body weight of more than 40 kg) are prescribed at 0.5 g 3 times a day, with severe infection, 0.75-1 g 3 times a day.

Children are prescribed as a suspension: at the age of 5-10 years - 0.25 g, 2-5 years - 0.125 g, under 2 years - 20 mg / kg 3 times a day, in case of severe infection - 60 mg / kg 3 times a day .

In preterm and newborns, the dose is reduced and / or the interval between doses is increased. The course of treatment is 5-12 days.

In acute uncomplicated gonorrhea, 3 g is administered once, while treating women, it is recommended to take the indicated dose again.

With acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, with gynecological infectious diseases for adults - 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With adult leptospirosis - 0.5-0.75 g 4 times a day for 6-12 days.

When adults are salmonelloson, 1.5–2 g 3 times daily for 2–4 weeks.

For the prevention of endocarditis with small surgical interventions for adults - 3-4 g for 1 hour before the procedure. If necessary, appoint a repeated dose after 8-9 hours. In children, reduce the dose by 2 times.

In patients with impaired renal function with a CC of 15-40 ml / min, the interval between doses is increased to 12 hours, with a CC below 10 ml / min, the dose is reduced by 15-50%, with anuria - the maximum dose of 2 g / day.

Pharmachologic effect

Semisynthetic penicillin, has a bactericidal effect, has a wide spectrum of action. Violates the synthesis of peptidoglycan (supporting polymer of the cell wall) during the period of division and growth, causes lysis of bacteria.

Active against aerobic gram-positive microorganisms: Staphylococcus spp. (with the exception of strains producing penicillinase), Streptococcus spp. and aerobic gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Penicillinase producing strains are resistant to amoxicillin.

Side effects

Allergic reactions: possible urticaria, skin flushing, erythematous rash, angioedema, rhinitis, conjunctivitis, rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, exudative erythema multiforme (including Stevens-a-John-John syndrome, chondroephritis-John syndrome, erythema-chondritis-erythema-chyne disease, in rare cases - anaphylactic shock.

On the part of the digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, a moderate increase in the activity of "liver" transaminases, rarely - pseudomembranous enterocolitis,

Nervous system disorders: agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, epileptic reactions.

Laboratory indicators: leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Others: shortness of breath, tachycardia, interstitial nephritis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or low body resistance). Overdosing. Symptoms: nausea, vomiting, diarrhea, disruption of water and electrolyte balance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, activated carbon, saline laxatives, drugs to maintain water and electrolyte balance, hemodialysis.

Special instructions

In the course of treatment it is necessary to monitor the state of the function of the blood-forming organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to it, which requires a corresponding change in antibacterial therapy.

If prescribed to patients with sepsis, a bacteriolysis reaction may be possible (the Jarish-Herxheimer reaction) (rarely).

In patients with hypersensitivity to penicillins, allergic cross-reactions with other beta-lactam antibiotics are possible.

In the treatment of mild diarrhea on the background of a course of treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin or attapulgitis containing antidiarrheal drugs can be used. In case of severe diarrhea, you should consult a doctor.

The treatment necessarily continues for another 48-72 hours after the disappearance of the clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use other or additional methods of contraception.

Interaction

Pharmaceutically incompatible with aminoglycosides (to avoid mutual inactivation, do not mix).

Antacids, glucosamine, laxatives, drugs, food, aminoglycosides slow down and reduce absorption, ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect, bacteriostatic drugs (macrolides, chloramphenicol, linkosamides, tetracyclines, sulfonamides) are antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index), reduces the effectiveness of estrogen-containing oral contraceptives, drugs, in the process of metabolism which produces PABK, ethinyl estradiol - the risk of bleeding "breakthrough."

Amoxicillin reduces clearance and increases the toxicity of methotrexate, enhances digoxin absorption.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, NSAIDs, and others. Drugs blocking tubular secretion, increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of skin rash.

Forms of release and composition

White or yellowish biconvex oblong pills with dividing notches on each side. Packed in 6 pieces in plastic blisters, 2 blisters in a carton box. For medical institutions it is planned to pack 6500 pieces in plastic containers or 10 pieces in plastic blisters, 100 blisters in a carton box.

Each tablet contains the active ingredient - amoxicillin trihydrate at a dosage of 1 g.

What helps

It is prescribed for bacterial infections that provoke:

  • diseases of ENT organs (sinusitis, sinusitis, otitis media),
  • respiratory diseases (bronchitis, pneumonia),
  • inflammation of the genitourinary system (cystitis, pyelonephritis, urethritis, etc.),
  • infectious pathologies of the skin and soft tissues (erysipelas, dermatosis).

It is also recommended for the treatment of dysentery, salmonellosis, meningitis and sepsis. It is prescribed for gastritis and stomach ulcers.

Amoxicillin is prescribed for cystitis.

Carefully

If you have a history of pathologies such as:

  • bronchial asthma,
  • allergic diathesis,
  • renal dysfunction,
  • blood diseases
  • Infectious mononucleosis,
  • lymphoblastic leukemia.

Caution is prescribed Amoxicillin to newborns.

Be wary appoint premature babies and newborns.

How to take Amoxicillin 1000

Orally Dosages and regimens are determined by the doctor in accordance with the course of clinical symptoms of infection.

Adults and adolescents over 10 years old with a body weight of more than 40 kg - 500 mg three times a day.

In severe cases, the dose of the drug can be increased to 1 g at a time.

Since the cardiovascular system

Tachycardia, phlebitis, blood pressure instability.


A side effect of using Amoxicillin can be diarrhea.
While taking Amoxicillin may be epigastric pain.
Tachycardia may be a reaction to taking Amoxicillin.

Skin rash, itching.

How to give Amoxicillin to 1000 children

According to the instructions for use appointed 3 times a day. It is appointed taking into account children's age:

  • from 5 to 10 years - 1 tsp. in the form of a suspension or 0.25 g tablets;
  • from 2 to 5 years old - by ¼ tsp. in the form of a suspension
  • from 0 to 2 years old - by ¼ tsp. in the form of a suspension.

Overdose

Due to the uncontrolled reception of the antibiotic may occur:

  • disorders of the gastrointestinal tract (nausea, vomiting, diarrhea, stomach pain),
  • development of water and electrolyte imbalance,
  • seizures
  • nephrotoxicity,
  • crystal water.

With uncontrolled intake of Amoxicillin, vomiting may begin.

In such cases, it is necessary to take activated charcoal and conduct symptomatic therapy. In case of severe poisoning, hospitalization is required.

Can I buy without a prescription

Most online pharmacies offer to buy this drug without prescription.

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Reviews of doctors and patients on Amoxicillin 1000

Gorodkova T.F., gastroenterologist, Ufa

Effective and inexpensive tool. I prescribe in eradication treatment regimens. It is well tolerated and causes almost no side effects. Allowed to children.

Elena, 28 years old, Tomsk

I always keep Amoxicillin Sandoz in my first-aid kit, as I regularly suffer from otitis and chronic sinusitis. Good helps with angina. For all the time of use, I did not observe any special manifestations of side effects. In a complex with this antibiotic I try to take Hilak Forte, therefore the symptoms of dysbacteriosis or thrush almost never appear. Quickly eliminates unpleasant symptoms during exacerbation of diseases.

Anastasia, 39 years old, Novosibirsk

I know that this drug is widely used in the treatment of bacterial infections in children and adults. Repeatedly used it herself. I was surprised that it is also widely used in veterinary medicine. Amoxicillin was prescribed to my cat when she had cystitis. Made only 3 shots every other day. The kitty is healthy and active again.

Watch the video: Amoxicillin. Bacterial Targets, Mechanism of Action, Adverse Effects. Antibiotic Lesson (February 2020).